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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NOS1 All Species: 23.33
Human Site: S859 Identified Species: 51.33
UniProt: P29475 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P29475 NP_000611.1 1434 160970 S859 S V S S Y S D S Q K S S G D G
Chimpanzee Pan troglodytes XP_001148238 1153 131137 T654 H L G A S Q L T P M G E G D E
Rhesus Macaque Macaca mulatta XP_001083352 1431 160593 S860 S V S S Y S D S Q K S S G D G
Dog Lupus familis XP_534695 1431 160627 S856 S V S S Y S D S H K S S G D G
Cat Felis silvestris
Mouse Mus musculus Q9Z0J4 1429 160454 S854 S V S S Y S D S R K S S G D G
Rat Rattus norvegicus P29476 1429 160541 S854 S V S S Y S D S R K S S G D G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506887 1152 131150 F653 A H E V D Q K F S Q L G A C Q
Chicken Gallus gallus Q90703 1136 129631 A637 E F C A F A H A I D Q K L S Q
Frog Xenopus laevis NP_001079155 1419 160392 A844 S V S S S A D A Q K S S A N E
Zebra Danio Brachydanio rerio NP_571735 1431 161840 T856 S V S S Y S D T R K S S S D E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q27571 1349 151696 R787 Q Q V K R I D R W D S L R G S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 45.3 96.1 94.2 N.A. 93.7 93.5 N.A. 44.6 44.7 78 74.3 N.A. 43.4 N.A. N.A. N.A.
Protein Similarity: 100 58.5 97.2 96.5 N.A. 95.9 96.3 N.A. 58.8 58.7 88.5 85.3 N.A. 59.2 N.A. N.A. N.A.
P-Site Identity: 100 13.3 100 93.3 N.A. 93.3 93.3 N.A. 0 0 60 73.3 N.A. 13.3 N.A. N.A. N.A.
P-Site Similarity: 100 33.3 100 93.3 N.A. 100 100 N.A. 13.3 26.6 80 86.6 N.A. 13.3 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 0 19 0 19 0 19 0 0 0 0 19 0 0 % A
% Cys: 0 0 10 0 0 0 0 0 0 0 0 0 0 10 0 % C
% Asp: 0 0 0 0 10 0 73 0 0 19 0 0 0 64 0 % D
% Glu: 10 0 10 0 0 0 0 0 0 0 0 10 0 0 28 % E
% Phe: 0 10 0 0 10 0 0 10 0 0 0 0 0 0 0 % F
% Gly: 0 0 10 0 0 0 0 0 0 0 10 10 55 10 46 % G
% His: 10 10 0 0 0 0 10 0 10 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 10 0 0 10 0 0 0 0 0 0 % I
% Lys: 0 0 0 10 0 0 10 0 0 64 0 10 0 0 0 % K
% Leu: 0 10 0 0 0 0 10 0 0 0 10 10 10 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % N
% Pro: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % P
% Gln: 10 10 0 0 0 19 0 0 28 10 10 0 0 0 19 % Q
% Arg: 0 0 0 0 10 0 0 10 28 0 0 0 10 0 0 % R
% Ser: 64 0 64 64 19 55 0 46 10 0 73 64 10 10 10 % S
% Thr: 0 0 0 0 0 0 0 19 0 0 0 0 0 0 0 % T
% Val: 0 64 10 10 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 55 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _